eCureMe logo
  eCureMe home eCureMe log In Sign Up!
eCureMe Life : Your Healthy Living. Click Here!
Welcome, eCureMe.com medical contents search October 25, 2013
       eCureMe Life
       Medical Supplies
       Calorie Count
       Self-Diagnosis
       Physician Search
       Message Board
      E-mail Doctor
      E-mail Veterinarian
      Self-Diagnosis
      Health-O-Matic Meter
      Calorie Count
      Natural Medicine
      Vitamins & Minerals
      Alternative Living
      My Health Chart
      Diseases & Treatments
      Atlas of Diseases
      Sexually Transmitted
      Diseases
      Drug Information
      Illegal Drugs
      Lab & Diagnostic Tests
      Internal Medicine
      Women’s Health
      Pediatrics
      Eye Disorders
      Skin Disorders
      Headache
      Mental Health
      Radiology
      Neurology
      Allergy
      Resource Links
      Physician Directory
      Dentist Directory
      Hospital Directory





Wegener's Granulomatosis

more about Wegener's Granulomatosis


  • Wegener's granulomatosis is due to an inflammation of the small blood vessels (vasculitis) and formation of granulomas (collection of cells) in the body.  This disease occurs in both men and women, usually affecting people 40 to 50 years old.  Without treatment, all patients with this disease will die.
  • The disease most often affects the lungs and kidneys.

  • Almost all patients with this disease have problems such as congestion of the nose, ear infections, sinus infections, or they develop large gums.  Many also develop coughs, have trouble breathing, or they cough-up blood.
  • Fever, night sweats, sores, or ulcers may form around the nostrils, while granulomas may block the nasal passages.
  • Other symptoms include one eye protruding out, Bruising, and joint pain.
  • This disease will eventually affect the kidneys of most patients, and can very quickly cause kidney failure.  Some patients may notice blood in their urine.
  • Some patients will have a "saddle" shaped nose due to the disease destroying parts of the nose.

  • This disease is caused by an inflammation and destruction of the small blood vessels in the body by the person's own immune system.  However, it is not known why the immune system attacks the person's own blood vessels.

  • Diagnosis is made by a biopsy, which involves obtaining a piece of tissue from the effected organ, and looking at it under the microscope.  The most common areas that undergo a biopsy are the lungs, kidney, or nose.
  • Blood tests for ANCA (antineutrophil cytoplasmic antibody) are usually positive in patients with Wegener's granulomatosis.

  • The goal is to make the diagnosis early and begin treatment before there is kidney failure.
  • The primary treatment is with the medicines cyclophosphamide (an anti-cancer drug) and prednisone (a steroid).  The disease can be stopped in up to 75% of patients treated with these medicines.  However, up to half of the patients who are successfully treated will eventually develop the disease again.
  • Also, there is an increased risk of developing cancer in those patients treated with cyclophosphamide.
  • Other drugs such as Methotrexate (an anti-cancer drug) and trimethoprim-sulfamethoxazole (an antibiotic) can be used to prevent repeat flare-ups of the disease.





more about Wegener's Granulomatosis


If you want your friend to read or know about this article, Click here






medical contents search

Home   |   About Us   |   Contact Us   |   Employment Ad   |   Help

Terms and Conditions under which this service is provided to you. Read our Privacy Policy.
Copyright © 2002 - 2003 eCureMe, Inc All right reserved.