eCureMe logo
  eCureMe home eCureMe log In Sign Up!
eCureMe Life : Your Healthy Living. Click Here!
Welcome, medical contents search May 10, 2013
       eCureMe Life
       Medical Supplies
       Calorie Count
       Physician Search
       Message Board
      E-mail Doctor
      E-mail Veterinarian
      Health-O-Matic Meter
      Calorie Count
      Natural Medicine
      Vitamins & Minerals
      Alternative Living
      My Health Chart
      Diseases & Treatments
      Atlas of Diseases
      Sexually Transmitted
      Drug Information
      Illegal Drugs
      Lab & Diagnostic Tests
      Internal Medicine
      Women’s Health
      Eye Disorders
      Skin Disorders
      Mental Health
      Resource Links
      Physician Directory
      Dentist Directory
      Hospital Directory


more about Histoplasmosis

  • This is a disease caused by the fungus Histoplasma capsulatum.  In the United States it is most commonly found in the central and eastern states.  It can also be found in Africa, Southeast Asia, Canada, Mexico, Central America and South America.
  • The fungus has two separate physical forms: one that is inhaled, called conidia; and a second, which results from converting the aerosol form to budding cells in the lungs.  From here, the fungus spreads through the bloodstream.  Most cases of Histoplasmosis do not cause symptoms or cause a mild flu-like illness (cough, body aches, etc.) lasting 1-15 days, depending on severity.  There are four types of Histoplasmosis infections that cause more severe syndromes listed below.

  • Chest X-Ray may show focal Pneumonia, progressive changes especially in the apices of the lungs, or a miliary pattern depending on the clinical syndrome.
  • Laboratory
  • Anemia or chronic disease is usually present in those with chronic lung disease
  • Bone marrow biopsy may show infection in disseminated disease
  • Alkaline phosphatase, LDH, and ferritin levels may be elevated
  • Urine antigen assay is 90% sensitive for diagnosing disseminated disease
  • Complement fixation titers in the serum are 80% sensitive for lung disease

  • Progressive localized disease and mild-moderate disease -- Itraconazole orally.  Amphotericin B intravenously is used for those who fail treatment.
  • Severe or disseminated disease -- intravenous amphotericin B.  Patients with AIDS and Histoplasmosis need life-long suppressive therapy with oral Itraconazole after treatment with intravenous Amphotericin.

  • Syndromes
    1. Acute Histoplasmosis -- person is very ill and has fever, but minimal lung complaints (even if a Histoplasmosis Pneumonia is present).  Usually lasts 1 week to six months, but is almost never fatal.
    2. Progressive disseminated Histoplasmosis -- cough, shortness of breath, fever, person feels very ill, loss of weight, and liver, spleen and adrenal glands are usually enlarged.  There may be ulcers in the mouth.  This syndrome can be fatal within six weeks especially without treatment.
    3. Chronic progressive pulmonary Histoplasmosis -- usually occurs in older patients with COPD (Emphysema or chronic Bronchitis).  It causes progressive lung damage.
    4. Disseminated disease in immunocompromised patients (e.g., on chemotherapy or has AIDS) -- person has fever and the Histoplasmosis can affect many different organs, including the meninges (causing Meningitis).  The chest X-Ray may show a diffuse pattern of involvement (miliary pattern).  Patients come to the hospital in shock.  Death usually occurs rapidly without treatment.

more about Histoplasmosis

If you want your friend to read or know about this article, Click here

medical contents search

Home   |   About Us   |   Contact Us   |   Employment Ad   |   Help

Terms and Conditions under which this service is provided to you. Read our Privacy Policy.
Copyright © 2002 - 2003 eCureMe, Inc All right reserved.