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Welcome, medical contents search April 25, 2013
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Abstral (Fentanyl)

Central nervous system agent


Breakthrough pain. Opioid therapy for underlying persistent cancer pain.

1. Adults: initially one 100mcg dose; if adequate analgesia is obtained within 30 min, continue to treat subsequent episodes with this dose. If inadequate, give 2nd dose after 30 min. For future episodes, if analgesia is not obtained with 100mcg dose, titrate in increments of 100mcg up to 400mcg as needed; if 400mcg is inadequate, titrate to 600mcg dose, then 800mcg dose if needed. May use 100mcg or 200mcg tablets for any single dose; max 4 tabs at one time. Max 2 doses/episode, up to 4 episodes/day. Wait at least 2 hrs before treating another episode. Wait at least 2 hrs before treating another episode. Maintenance: use only one tablet of appropriate strength. 2. Children: Under age of 18: not recommended.

Category C

Nause, drowsiness, headache, headache, constipation, respiratory/circulatory depression.

Pregnancy Risk Categories defined:

A: Studies in pregnant women failed to show a risk to the fetus in the first trimester - with no evidence of risk in the later trimesters.

B: Animals studies indicate no adverse effect to the fetus, but there are no adequate, clinical studies in pregnant women.

C: Animal studies have shown an adverse effect on the fetus, but there are no adequate, clinical studies in humans. Despite potential risks, the drug may be useful in pregnant women.

D: There is evidence of risk to the human fetus, but the potential benefits of use in pregnant women may be acceptable, despite potential risks.

X: Studies in animals or humans show fetal abnormalities, or adverse reaction reports indicate evidence of fetal risk. Warning: the risks involved clearly outweigh any potential benefit from using the drug in pregnant women, regardless of trimester.

NR: Not rated (i.e., no information available at this time as to the potential risks or benefits).

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