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Welcome, medical contents search April 30, 2013
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Abacavir Sulfate (Ziagen)

Systemic anti-infective

Antiretroviral agent

Ziagen is indicated for the treatment of HIV Infection in combination with other antiviral agents. While not a cure for HIV, such drugs may suppress the replication of the virus and delay the progression of the disease.

Adults: 300 mg twice daily in combination with other antiretroviral agents. Adolescents and pediatric patients (children 3 months to 16 years): 8 mg per 1 kg (2.2 lb) of body weight 2 times a day in combination with other drugs for HIV. Children should not take more than 300 mg twice a day.

Category C

Nausea, vomiting Diarrhea, loss of appetite, and insomnia. Hypersensitivity reaction: fever, skin rash, fatigue, nausea, vomiting, Diarrhea, abdominal pain, weakness, lethargy, muscle and joint pain, swelling, shortness of breath, numbness, tingling sensation, dry mouth, and lactic acidosis. If you have symptoms of hypersensitivity, contact your doctor immediately.

Pregnancy Risk Categories defined:

A: Studies in pregnant women failed to show a risk to the fetus in the first trimester - with no evidence of risk in the later trimesters.

B: Animals studies indicate no adverse effect to the fetus, but there are no adequate, clinical studies in pregnant women.

C: Animal studies have shown an adverse effect on the fetus, but there are no adequate, clinical studies in humans. Despite potential risks, the drug may be useful in pregnant women.

D: There is evidence of risk to the human fetus, but the potential benefits of use in pregnant women may be acceptable, despite potential risks.

X: Studies in animals or humans show fetal abnormalities, or adverse reaction reports indicate evidence of fetal risk. Warning: the risks involved clearly outweigh any potential benefit from using the drug in pregnant women, regardless of trimester.

NR: Not rated (i.e., no information available at this time as to the potential risks or benefits).

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