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Welcome, eCureMe.com medical contents search April 25, 2013
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Endometrial Cancer


Description

  • Endometrial cancer occurs most often in women 50-70 years of age.
  • This is a very treatable cancer, with over 80% survival after 5 years. The earlier it is detected the better the prognosis
  • In pre-menopausal women, the incidence of endometrial cancer (EC) is 5 times lower than the incidence of cervical cancer, but after 70 years of age they occur at the same frequency.
  • There are two types of EC: type I and type II. Type I is estrogen-dependent, which appears mostly in pre- and perimenopausal women.
  • Type II EC is estrogen-independent and is diagnosed mostly in postmenopausal women, thin and fertile women, or in women with normal menstrual cycles. It is aggressive and has a worse prognosis than type I.



    Risk Factors

  • Never having been pregnant
  • Obesity
  • Diabetes
  • Polycystic ovary disease
  • Taking estrogen without progesterone
  • Tamoxifen use, a medication for breast cancer
  • Symptoms
  • Vaginal bleeding
  • Pus from vagina
  • Lower abdominal pain



    Diagnosis

  • Endometrial biopsy
  • Hysteroscopy (scope passed through the cervix into the uterus)
  • Ultrasound
  • MRI



    Similar Conditions

  • Ovarian cancer
  • Uterine fibroids



    Treatment

  • Total hysterectomy, including the ovaries
  • Radiation treatment for more severe cases
  • Progestins for advanced cancers



    Prevention

  • Progesterone (e.g., Provera) should be given in conjunction with estrogen replacement therapy during menopause.
  • Women being treated for breast cancer now receive Tamoxifen for shorter durations, usually only 5 years. Consult an oncologist (cancer specialist) for exact recommendations.













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