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Angioneurotic Edema

more about Angioneurotic Edema


Angioedema

  • This is a syndrome of swelling in the deep layers of the skin.  Lip swelling is usually prominent.  It is often associated with Urticaria (hives).
  • Angioedema is often caused by an allergic type reaction (i.e., the body's defense system mistakenly goes off, initiating reactions in the body).  This occurs because histamine released from mast cells starts a cascade of events that result in allergy and Angioedema.

  • Lip swelling
  • Eyelid swelling
  • Tongue swelling
  • Hives
  • Nausea/vomiting
  • Intermittent sharp abdominal pain
  • History of sudden onset of shortness of breath

  • Allergic sensitivities
    1. Pollens
    2. Foods (i.e., shellfish, eggs, nuts, chocolate, tomatoes, milk, and berries)
    3. Medications
    4. Molds
    5. Bee stings
    6. Venom
    7. Dermographism (a form of Urticaria)
    8. Cold
    9. Light
    10. Exercise
    11. Inherited forms (genetic) hereditary Angioedema or HEA
    12. Complement mediated (an immune pathway)
    13. Medications (nonallergic, but direct cause, such as ACE inhibitors)
    14. Aspirin
    15. Other anti-inflammatories
    16. Dyes
    17. Chemicals
    18. Emotional stress
    19. Unknown

  • Examination:
    1. Swelling of lips, eyelid or tongue -- usually resolves within 72 hours.
    2. There is very little aching.
    3. Hives may or may not be present.
    4. Stridor (wheezing in neck area)
  • Laboratory findings may include:
    1. Abnormal complement levels (i.e., C4, C1 assay may help in diagnosing HAE)
    2. Vasculitis workup may be done (ANA, RA, CBC, ESR) if no other etiology for Angioedema is found.
    3. Rarely, skin biopsy is needed.

  • Medications
    1. Antihistamines (e.g., Hydroxyzine for acute attacks)
    2. Doxepin (an older antidepressant) helps with chronic (continuous) form
    3. Calcium channel blockers
    4. Terbutaline
    5. Colchicine
    6. Danazol
  • Plasmapheresis (exchange of plasma in blood) used for rare unresponsive chronic forms

  • Angioedema can be life threatening.  Seek emergency medical treatment.

  • Identify and eliminate causative agents.  Special diets may be prescribed.

  • Hives
  • Allergic reactions

  • Note

- Angioedema often involves complicated immune chemical pathways.  Often your primary care physician will need to refer you to allergy specialists in order to properly treat your condition.





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