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Erythroblastosis Fetalis

more about Erythroblastosis Fetalis


Hemolytic disease of the newborn



  • This condition develops in a fetus when antibodies produced by the mother attack the fetus's red blood cells.

  • Baby can die in some cases.
  • Yellowish skin and eye discoloration within 24 hours after birth
  • Hydrops Fetalis (severe form)
    1. Pallor
    2. An enlarged liver and/or spleen
    3. Generalized swelling
    4. Respiratory distress
    5. Petechiae, purpura
    6. Death in uterus or shortly after birth

  • It is caused by the passage of maternal antibodies via the placenta when there is a difference in blood type between the pregnant mother and the fetus.
    1. RH Incompatibility
    2. ABO incompatibility
    3. Other blood group incompatibilities such as c, E, Kell(K)

  • Based on history
  • Lab findings

    1. Peripheral blood morphology shows increased reticulocyte, nucleated red blood cells
    2. Positive Coombs test

  • Before birth:
    1. Intrauterine transfusion
    2. Early induction of labor when pulmonary maturity attained, fetal distress is present, or 35-37 weeks of gestation
  • After birth:
    1. It depends on severity
    2. Temperature stabilization, monitoring
    3. Phototherapy
    4. Transfusion with compatible packed red blood 
    5. Exchange transfusion
    6. Sodium bicarbonate for correction of acidosis
    7. Assisted ventilation

  • Kernicterus
  • Hepatosplenomegaly
  • Inspissated (thickened or dried) bile syndrome
  • Greenish staining of teeth

  • Contact the doctor if your child has severe jaundice, if jaundice lasts longer than 1 or 2 weeks, or if other symptoms develop.

  • Acquired hemolytic anemia
  • Congenital toxoplasma, syphilis infection
  • Congenital obstruction of bile duct
  • Cytomegalovirus infection




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