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Disseminated Intravascular Coagulopathy

more about Disseminated Intravascular Coagulopathy


DIC, Consumption coagulopathy



  • Activation of the clotting cascade within the blood vessels causes the ordinarily liquid blood to clot.  The utilization of a large percentage of the available clotting factors leads to generalized bleeding.

  • Prolonged bleeding from any site
  • Sudden appearance of multiple ecchymoses (black-and-blue marks)
  • Petechial rash

  • Any process that activates the clotting cascade

  • Microscopic examination of a blood smear shows fragmented RBC's and decreased numbers of platelets.
  • Abnormal blood tests:
  • Increased fibrin split products
  • Prothrombin time (PT) and partial thromboplastin time (PTT) are prolonged.

  • Serious infection (viral, bacterial, rickettsial)
  • Serious Trauma
  • Shock
  • Cancer
  • Incompatible blood transfusion
  • Severe liver disease

  • Various treatment plans in various situations:
  • Fresh frozen plasma, to replace several clotting factors that have been consumed
  • Cryoprecipitate
  • Platelet transfusions
  • Heparin

  • Increasingly severe bleeding
  • Organ damage

  • Appropriate emergency management by physician
  • At times, a hematologist is consulted.

  • Any bleeding disorder




more about Disseminated Intravascular Coagulopathy


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