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Schoenlein-Henoch Purpura

more about Schoenlein-Henoch Purpura

Henoch-Schoenlein purpura, Anaphylactoid purpura, Vascular purpura, Allergic purpura

  • This is an inflammatory response within the blood vessels and/or capillaries.
  • It is characterized by purple spots on the skin, joint pain, gastrointestinal symptoms, and kidney disorder.
  • It usually occurs in children ages 2 - 8.
  • It is more common in boys than girls.

  • Primarily, redness and swelling of the skin caused by congestion of the capillaries.
  • Purple spots (wheals) -- usually on the lower extremities and buttocks, but may involve elbows, trunk, and face
  • Lack of energy
  • Low-grade fever
  • Joint pains
  • Nausea/vomiting
  • Abdominal pain
  • Diarrhea
  • Bloody stools
  • Painful Menstruation

  • The exact cause is unknown, but it is related to an abnormal response of the immune system.
  • It can be associated with allergy or drug sensitivity.

  • Based on physical examination
  • Blood tests show increased white blood cells, increased eosinophils, and elevated erythrocyte sedimentation rate (ESR).
  • Urine tests show microscopic blood in the urine.
  • Skin biopsy shows vasculitis.

  • Symptomatic treatment.
  • Nonsteroidal anti-inflammatory drugs
  • Corticosteroid therapy for central nervous system manifestations, nephritic syndrome, or acute phase complications, such as intestinal hemorrhage, obstruction, or perforation.
  • Azathioprine or cyclophosphamide for severe nephritis

  • Intestinal hemorrhage
  • Intestinal obstruction
  • Intussusception
  • Intestinal perforation

  • This condition usually resolves spontaneously within one week without treatment, but may recur several times before complete remission.
  • Death can occur from gastrointestinal complications, renal failure, or central nervous system involvement, but these outcomes are very rare.

  • Sepsis
  • Rheumatic disease
  • Polyarteritis nodosa

more about Schoenlein-Henoch Purpura

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