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Wellbutrin (Bupropion HCI)
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Central nervous system agent
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Antidepressant
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Depression, occasionally used to decrease cigarette craving.
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(Adults) Begin at 100 mg twice daily; increase to 100 mg 3 times daily on 4th day if needed. Max. 450 mg/day, before or after meal.
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Category B
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Agitation, Insomnia, headache, dry mouth, nausea, Constipation, tremor, rashes, Seizures, Seizures, arrhythmias, Blurred Vision, dyspepsia, urine retention, pruritus.
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Pregnancy Risk Categories defined:
A: Studies in pregnant women failed to show a risk to the fetus in the first
trimester - with no evidence of risk in the later trimesters.
B: Animals studies indicate no adverse effect to the fetus, but there are no adequate,
clinical studies in pregnant women.
C: Animal studies have shown an adverse effect on the fetus, but there are no adequate,
clinical studies in humans. Despite potential risks, the drug may be useful in pregnant
women.
D: There is evidence of risk to the human fetus, but the potential benefits of use in
pregnant women may be acceptable, despite potential risks.
X: Studies in animals or humans show fetal abnormalities, or adverse reaction reports
indicate evidence of fetal risk. Warning: the risks involved clearly outweigh any
potential benefit from using the drug in pregnant women, regardless of trimester.
NR: Not rated (i.e., no information available at this time as to the potential
risks or benefits).
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