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Acetadote (Acetylcysteine)
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Poison and drug dependence
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Poisoning/overdose
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Hepatic injury after acetaminophen overdose.
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Adults & children: give within 8 hours of overdose or ¡Â24 hours if time of overdose is unknown. Loading dose: 150mg/kg IV infusion, given over 60 minutes. Maintenace: 50mg/kg given over 4 hours, then 100mg/kg given over 16 hours.
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Category B
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Rash, urticaria, facial flushing, itching, edema, tachycardia, hypotension, GI upset
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Pregnancy Risk Categories defined:
A: Studies in pregnant women failed to show a risk to the fetus in the first
trimester - with no evidence of risk in the later trimesters.
B: Animals studies indicate no adverse effect to the fetus, but there are no adequate,
clinical studies in pregnant women.
C: Animal studies have shown an adverse effect on the fetus, but there are no adequate,
clinical studies in humans. Despite potential risks, the drug may be useful in pregnant
women.
D: There is evidence of risk to the human fetus, but the potential benefits of use in
pregnant women may be acceptable, despite potential risks.
X: Studies in animals or humans show fetal abnormalities, or adverse reaction reports
indicate evidence of fetal risk. Warning: the risks involved clearly outweigh any
potential benefit from using the drug in pregnant women, regardless of trimester.
NR: Not rated (i.e., no information available at this time as to the potential
risks or benefits).
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